Kenzou Tenma, a brilliant Japanese brain surgeon working in Germany, saves the life of a small boy who has been shot in the head. Little does he know that doing so would destroy his entire career at the hospital and that his fiancé would leave him. When the hospital director and doctors of the hospital staff are suddenly murdered, he gets a second chance but also renders him as the main suspect to the murders. Life goes on for Tenma as he saves people at the hospital, and he goes back to the joy of being a surgeon again.